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Image Search Results
Journal: Journal of Clinical Investigation
Article Title: A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer
doi: 10.1172/jci154074
Figure Lengend Snippet: Figure 6. Elevated CGA and GATA2 expression levels in GC patients after chemotherapy. (A and B) IHC staining of CGA, p-EGFR, and GATA2 in 6 repre- sentative nonresponsive human GC specimens (n = 31) obtained before and after chemotherapy (A). Scale bar: 50 μm. IHC scores of p-EGFR and GATA2 are shown (B). The CGA images are the same as shown in Figure 1D. (C) Association between CGA and p-EGFR or GATA2 levels in nonresponsive GC specimens (n = 31) obtained after chemotherapy. (D) ELISA of CGA levels in plasma samples from healthy donors (normal, n = 57), newly diagnosed GC patients (non-chemo, n = 42), and neoadjuvant (n = 41) or palliative (n = 56) chemotherapy–treated GC patients. (E) Left: ELISA of plasma CGA from GC patients who received neoadjuvant chemotherapy with a partial response (PR, n = 9) or stable disease (SD, n = 31) status. Right: ELISA of plasma CGA from post- and preoperative samples of GC patients (n = 15) who received neoadjuvant chemotherapy. (F) Left: ELISA of plasma CGA from GC patients (n = 46) before and after palliative chemotherapy. Right: ELISA of plasma CGA from GC patients who received palliative chemotherapy and had progressive disease (PD, n = 30) or SD (n = 26) status. (G) Log-rank test for overall survival of GC patients (n = 64) with different CGA levels after neoadjuvant or palliative chemo- therapy. Data are presented as mean ± SEM. P value was calculated by Wilcoxon’s matched-pairs signed-rank test (B), by χ2 test (C), by 1-way ANOVA with Bonferroni’s post hoc test (D), or by Student’s t test (E and F).
Article Snippet: A
Techniques: Expressing, Immunohistochemistry, Enzyme-linked Immunosorbent Assay, Clinical Proteomics